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What is the best time to take levothyroxine? Typically, patients are advised to take their levothyroxine first thing in the morning, at least 30 minutes but preferably an hour before eating, on an empty stomach and with only water. The goal is to achieve consistency in taking the medication to avoid fluctuations in thyroid levels and variable control of symptoms. Does magnesium interfere with thyroid medication? Magnesium and Thyroid Meds Magnesium can impair the absorption of thyroid medications, so please space out magnesium by 4 hours from your thyroid medications. For most conditions, I generally recommend taking magnesium at bedtime. Can hypothyroidism cause swelling in hands and feet? For some people, hypothyroidism can contribute to joint and muscle problems. Specifically, hypothyroidism may lead to: Muscle aches, tenderness and stiffness, especially in the shoulders and hips. Swelling of the small joints in the hands and feet. What medications should not be taken with levothyroxine? Drugs that Impair Levothyroxine Absorption A number of drugs have been shown to impair the absorption of levothyroxine ; these drugs include calcium carbonate, aluminum- containing antacids, sucralfate, iron supplements, cholestyramine, sevelamer, and, possibly, ciprofloxacin, raloxifene, and orlistat.
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